Chronic hypernatraemia due to osmoreceptor dysfunction

Abstract

Plasma osmolality is regulated by the interaction of the kidneys, arginine vasopressin (AVP), and thirst - the last two being stimulated by hypothalamic osmoreceptor signals. Osmoreceptor dysfunction may cause hypernatraemia, hyperviscosity and considerable morbidity, and may be associated with other endocrine dysfunction. We report two patients with chronic hypernatraemia and osmoreceptor dysfunction.  

doi: 10.4038/cmj.v53.i3.258

Ceylon Medical Journal Vol. 53, No. 3, September 2008 pp111-112